Мойзес Веласкес-Манофф - Эпидемия стерильности

Gehan A. Mostafa, Abeer Al Shehab, Nermeen R. Fouad. “Frequency of CD4+CD25 high Regulatory T-cells in Peripheral Blood of Egyptian Children with Autism”. Journal of Child Neurology 25, № 3 (2009).

Michael G. Chez, Natalie Guido-Estrada. “Immune Therapy in Autism: Historical Experience and Future Directions with Immunomodulatory Therapy”. Neurotherapeutics 7, № 3 (2010).

Sudhir Gupta, Daljeet Samra, Sudhanshu Agrawal. “Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin”. Journal of Clinical Immunology 30, Suppl. 1 (2010).

M. S. Maddur et al. “Immunomodulation by Intravenous Immunoglobulin: Role of Regulatory T-cells”. Journal of Clinical Immunology 30, Suppl. 1 (2010).

Более подробную информацию о дисфункции кишечника в случае аутизма можно найти здесь: Valicenti-McDermott et al. “Gastrointestinal Symptoms in Children with an Autism Spectrum Disorder and Language Regression”. Pediatric Neurology 39, № 6 (December 2008): 392–398.

Аргументы в пользу того, что у детей-аутистов действительно отмечается дисфункция желудочно-кишечного тракта, можно найти здесь: Amy C. Brown, Lewis Mehl-Madrona. “Autoimmune and Gastrointestinal Dysfunctions: Does a Subset of Children with Autism Reveal a Broader Connection?” Expert Review of Gastroenterology & Hepatology 5, № 4 (2011).

Harumi Jyonouchi et al. “Evaluation of an Association Between Gastrointestinal Symptoms and Cytokine Production Against Common Dietary Proteins in Children with Autism Spectrum Disorders”. Journal of Pediatrics 146, № 5 (2005).

Timothy Buie et al. “Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals with ASDs: A Consensus Report”. Pediatrics 125, Suppl. 1 (2010).

R. H. Sandler et al. “Relief of Psychiatric Symptoms in a Patient with Crohn’s Disease after Metronidazole Therapy”. Clinical Infectious Diseases 30, № 1 (2000).

Stephen J. Genuis, Tomas P. Bouchard. “Celiac Disease Presenting as Autism”. Journal of Child Neurology 25, № 1 (2010); S. J. Genuis. “Is Autism Reversible?” Acta Paediatrica 98, № 10 (2009).

Giulia Barcia et al. “Autism and Coeliac Disease”. Journal of Autism and Developmental Disorders 38, № 2 (2008).

Enzo Emanuele et al. “Low-grade Endotoxemia in Patients with Severe Autism”. Neuroscience Letters 471, № 3 (2010).

R. H. Sandler et al. “Short-term Benefit from Oral Vancomycin Treatment of Regressive-onset Autism”. Journal of Child Neurology 15, № 7 (2000).

Sydney M. Finegold. “Desulfovibrio Species Are Potentially Important in Regressive Autism”. Medical Hypotheses 77, № 2 (2011); Sydney M. Finegold. “State of the Art; Microbiology in Health and Disease. Intestinal Bacterial Flora in Autism”. Anaerobe (2011); Sydney M. Finegold et al. “Pyrosequencing Study of Fecal Microflora of Autistic and Control Children”. Anaerobe 16, № 4 (2010).

K. A. Foley et al. “Propionic Acid Alters Startle Response Magnitude in Adolescent Rats” (2011).

Rochellys Diaz Heijtz et al. “Normal Gut Microbiota Modulates Brain Development and Behavior”. Proceedings of the National Academy of Sciences 108, № 7 (2011).

M. R. Buehler. “A Proposed Mechanism for Autism: An Aberrant Neuroimmune Response Manifested as a Psychiatric Disorder”. Medical Hypotheses 76, № 6 (2011).

T. Haahtela. “Allergy Is Rare Where Butterflies Flourish in a Biodiverse Environment”. Allergy 64, № 12 (2009).

Хороший обзор этой темы см.: E. Magen et al. “Can Worms Defend Our Hearts? Chronic Helminthic Infections May Attenuate the Development of Cardiovascular Diseases”. Medical Hypotheses 64, № 5 (2005).

M. J. Doenhoff et al. “An Anti-atherogenic Effect of Schistosoma mansoni Infections in Mice Associated with a Parasite-induced Lowering of Blood Total Cholesterol”. Parasitology 125, № 5 (2002).

V. S. Zhdanov et al. “Development of Atherosclerosis over a 25-Year Period: An Epidemiological Autopsy Study in Males of 11 Towns”. International Journal of Cardiology 68, № 1 (1999); K. S. Woo et al. “Westernization of Chinese Adults and Increased Subclinical Atherosclerosis”. Arteriosclerosis, Thrombosis, and Vascular Biology 19, № 10 (1999).

A. R. Walker. “Survival Rate at Middle Age in Developing and Western Populations”. Postgraduate Medical Journal 50, № 579 (1974).

В Финляндии ученые обнаружили, что перенесенная в начале жизни инфекция может защитить от сердечно-сосудистых заболеваний на склоне лет. В то время как у финнов с антителами к взрослым вирусам действительно чаще развивались сердечные заболевания (что поддерживает парадигму о существовании прямой зависимости между инфекционными и сердечными заболеваниями), у тех из них, кто чаще болел в детстве, более низкий риск развития сердечно-сосудистых заболеваний. При этом чем больше число болезней, которыми человек страдал в детстве, тем ниже у него риск сердечных заболеваний в пожилом возрасте. Erkki Pesonen et al. “Dual Role of Infections as Risk Factors for Coronary Heart Disease”. Atherosclerosis 192, № 2 (2007).

Tomas W. McDade et al. “Early Origins of Inflammation: Microbial Exposures in Infancy Predict Lower Levels of C-reactive Protein in Adulthood”. Proceedings of the Royal Society B: Biological Sciences 277, № 1684 (2010).

Tomas W. McDade, Stacy Tessler Lindau, Kristen Wroblewski. “Predictors of C-reactive Protein in the National Social Life, Health, and Aging Project”. Journals of Gerontology: Series B, Psychological Sciences and Social Sciences 66, № 1 (2011).

Yael T. Joffe et al. “Tumor Necrosis Factor-alpha Gene-308 G/A Polymorphism Modulates the Relationship Between Dietary Fat Intake, Serum Lipids, and Obesity Risk in Black South African Women”. Journal of Nutrition 140, № 5 (2010).

Davina Wu et al. “Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis”. Science 332, № 6026 (2011). Более подробную информацию о гельминтах и восстановлении тканей см.: F. Chen et al. “An Essential Role for T H2-type Responses in Limiting Acute Tissue Damage During Experimental Helminth Infection”. Nature Medicine 18, № 2 (2012).

Rick M. Maizels, Judith E. Allen. “Immunology: Eosinophils Forestall Obesity”. Science 332, № 6026 (2011).

S. H. Vermund, S. MacLeod. “Is Pinworm a Vanishing Infection? Laboratory Surveillance in a New York City Medical Center from 1971 to 1986”. American Journal of Diseases of Children 142, № 5 (1988).

S-L. Huang, P-F. Tsai, Y-F. Yeh. “Negative Association of Enterobius Infestation with Asthma and Rhinitis in Primary School Children in Taipei”. Clinical and Experimental Allergy 32, № 7 (2002).

Kathrin Eller et al. “Potential Role of Regulatory T-cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy”. Diabetes 60, № 11 (2011).

Интересно то, что высокий индекс массы тела у матери является предиктором бронхиальной обструкции только в случае детей, у родителей которых еще нет аллергии. Swatee P. Patel et al. “Associations between Pre-pregnancy Obesity and Asthma Symptoms in Adolescents”. Journal of Epidemiology & Community Health (2011).

O. Schaefer. “When the Eskimo Comes to Town”. Nature Today 6 (1971); H. Herxheimer, O. Schaefer. “Letter: Asthma in Canadian Eskimos”. New England Journal of Medicine 291, № 26 (1974).

O. Schaefer. “Etiology of Appendicitis”. British Medical Journal 1, № 6172 (1979).

J. A. Hildes, O. Schaefer. “The Changing Picture of Neoplastic Disease in the Western and Central Canadian Arctic (1950–1980)”. Canadian Medical Association Journal 130, № 1 (1984).

“Occupation, Health, and Mortality in the Light of the Registrar-General’s Decennial Supplement”. Lancet 211, № 5449 (1928; Francesco Colotta et al. “Cancer-related Inflammation, the Seventh Hallmark of Cancer: Links to Genetic Instability”. Carcinogenesis 30, № 7 (2009).

Graham A. W. Rook, Angus Dalgleish. “Infection, Immunoregulation, and Cancer”. Immunological Reviews 240, № 1 (2011); Leena C. Von Hertzen, H. Joensuu, T. Haahtela. “Microbial Deprivation, Inflammation and Cancer”. Cancer Metastasis Reviews 30, № 2 (2011).

Anamaria Savu et al. “Breast Cancer and Microbial Cancer Incidence in Female Populations around the World: A Surprising Hyperbolic Association”. International Journal of Cancer 123, № 5 (2008).

Paulo S. Pinheiro et al. “Cancer Incidence in First Generation U.S. Hispanics: Cubans, Mexicans, Puerto Ricans, and New Latinos”. Cancer Epidemiology, Biomarkers & Prevention 18, № 8 (2009).

W. Li et al. “Occupational Risk Factors for Pancreatic Cancer among Female Textile Workers in Shanghai, China”. Occupational and Environmental Medicine 63, № 12 (2006); George Astrakianakis et al. “Lung Cancer Risk among Female Textile Workers Exposed to Endotoxin”. Journal of the National Cancer Institute 99, № 5 (2007); Roberta M. Ray et al. “Occupational Exposures and Breast Cancer among Women Textile Workers in Shanghai”. Epidemiology 18, № 3 (2007); Karen J. Wernli et al. “Occupational Exposures and Ovarian Cancer in Textile Workers”. Epidemiology 19, № 2 (2008).

G. Mastrangelo et al. “Lung and Other Cancer Site Mortality in a Cohort of Italian Cotton Mill Workers”. Occupational and Environmental Medicine 65, № 10 (2008); G. Mastrangelo, V. Marzia, G. Marcer, “Reduced Lung Cancer Mortality in Dairy Farmers: Is Endotoxin Exposure the Key Factor?” American Journal of Industrial Medicine 30, № 5 (1996).