Брюс Блумберг - ЖироГен. Почему мы едим все меньше, тренируемся все больше, а худеем все хуже

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Можно привести аргумент о том, что сироп с высоким содержанием фруктозы нарушает передачу гормональных сигналов совсем не так, как полагает Агентство по охране окружающей среды США. Такой взгляд на эндокринные нарушения весьма ограничен. Нарушение какого-либо из сигнальных путей гормонов (например, лептина, инсулина, гормона роста и т. д.) имеет неблагоприятные биологические последствия, которые необходимо учитывать. Еще более важно то, что нарушение любых сигнальных путей в клетке, даже если это не пути гормонов, может привести к изменению биологических функций. Мой японский коллега Йун Канно ввел понятие «токсичность сигнала» для выявления химических веществ, которые нарушают рецепторные сигнальные пути в клетке. Эта концепция значительно расширяет область эндокринных нарушений: токсичность сигнала следует также включить в причины нарушения обмена веществ.

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