Ли Ноу - Эгоистичная митохондрия. Как сохранить здоровье и отодвинуть старость
- Название:Эгоистичная митохондрия. Как сохранить здоровье и отодвинуть старость
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- Издательство:Питер
- Год:2020
- Город:Санкт-Петербург
- ISBN:978-5-4461-1021-6
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Ли Ноу - Эгоистичная митохондрия. Как сохранить здоровье и отодвинуть старость краткое содержание
В нашем организме работают крошечные «энергетические станции» — митохондрии. Именно они отвечают за наше здоровье и отличное самочувствие. Когда они работают хорошо, мы не испытываем недостатка в энергии. А когда плохо — страдаем от заболеваний. Доктор Ли Ноу открывает тайну: заболевания, которые кажутся не связанными между собой на первый взгляд: диабет, рак, шизофрения, хроническая усталость, болезнь Паркинсона и другие — имеют общую природу.
Сегодня нам известно, как улучшить работу митохондрий, обеспечивающих организм энергией на 90 %. В этой книге вас ждет актуальная информация о питании, образе жизни, кетогенной диете и добавках, которые возвращают здоровье митохондриям, а следовательно, и нам.
Эгоистичная митохондрия. Как сохранить здоровье и отодвинуть старость - читать онлайн бесплатно ознакомительный отрывок
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Moreira P. I., et al. Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimers Dis. 2007 Sep; 12(2):195–206.
Nair R. R., Nair P. Alteration of myocardial mechanics in marginal magnesium deficiency. Magnes Res. 2002 Dec; 15(3–4):287–306.
Nakayama S., et al. Mechanisms for monovalent cation-dependent depletion of intracellular Mg2+:Na(+)-independent Mg2+ pathways in guinea-pig smooth muscle. J Physiol. 2003 Sep 15;551(Pt 3):843–53. doi:10.1113/ jphysiol.2003.047795.
Paolisso G., Barbagallo M. Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium. Am J Hyperten. 1997 Mar 1;10(3):346–55. doi:10.1016/S0895 -7061(96)00342-1.
Resnick L. M., et al. Cellular-free magnesium depletion in brain and muscle of normal and preeclamptic pregnancy: a nuclear magnetic resonance spectroscopic study. Hypertension. 2004 Sep:44(3):322–6. doi:10.1161/01. HYP.0000137592.76535.8c.
Rubenowitz E., Axelsson G., Rylander R. Magnesium in drinking water and death from myocardial infarction. Am J Epidemiol. l996; 143:456–62.
Sinatra S. T. The Sinatra solution: metabolic cardiology. Laguna Beach, CA: Basic Health Publications, Inc; 2011.
Takaya J., Higashino H., Kobayashi Y. Intracellular magnesium and insulin resistance. Magnes Res. 2004 Jun; 17(2):126–36.
Touyz R. M. Role of magnesium in the pathogenesis of hypertension. Mol Aspects Med. 2003 Feb — Jun; 24(1–3):107–36. doi:10.1016/S0098-2997(02)00094-8.
Touyz R. M., et al. Effects of low dietary magnesium intake on development of hypertension in stroke-prone spontaneously hypertensive rats: role of reactive oxygen species. J Hypertens. 2002 Nov; 20(11):2221–32.
Biewenga G. P., Haenen G. R., Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol. 1997 Sep; 29(3):315–31. doi:10.1016/ S0306-3623(96)00474-0.
Femiano F., Scully C. Burning mouth syndrome (BMS): double blind controlled study of alphalipoic acid (thioctic acid) therapy. J Oral Pathol Med. 2002 May; 31(5):267–9. doi:10.1034/j.1600–0714.2002.310503.
Hagen T. M., et al. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J. 1999 Feb; 13(2):411–8.
Hagen T. M., et al. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc Natl Acad Sci USA. 2002 Feb 19; 99(4):1870–5. doi:10.1073/ pnas.261708898.
Hagen T. M., et al. Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid. Ann NY Acad Sci. 2002 Apr; 959:491–507. doi:10.1111/j.1749–6632.2002.tb02119.
Hager K., et al. Alpha-lipoic acid as a new treatment option for Alzheimer type dementia. Arch Gerontol Geriatr. 2001 Jun; 32(3):275–82.
Jia L., et al. Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci. 2007 Jan; 48(1):339–48. doi:10.1167/iovs.06-0248.
Jiang T., et al. Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway. Aging Cell. 2013 Dec; 12(6):1021–31. doi:10.1111/acel.12127. doi:10.1111/acel.12127.
Kim D. C., et al. Lipoic acid prevents the changes of intracellular lipid partitioning by free fatty acid. Gut Liver. 2013 Mar; 7(2):221–7. doi:10.5009/ gnl.2013.7.2.221.
Li C. J., et al. Attenuation of myocardial apoptosis by alpha-lipoic acid through suppression of mitochondrial oxidative stress to reduce diabetic cardiomyopathy. Chin Med J (Engl). 2009 Nov 5; 122(21):2580–6.
Liu J., Killilea D. W., Ames B. N. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1876–81. doi:10.1073/pnas.261709098.
Liu J, et al. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann NY Acad Sci. 2002 Apr;959:133– 66. doi:10.1111/j.1749–6632.2002.tb02090.x.
Liu J., et al. Memory loss in old rats is associated with brain mitochondrial decay and RNA/ DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha- lipoic acid. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2356–61. doi:10.1073/pnas.261709299.
Meydani M., et al. The effect of long-term dietary supplementation with antioxidants. Ann NY Acad Sci. 1998 Nov 20; 854:352–60. doi:10.1111/j.1749–6632.1998.tb09915.
Nyengaard J. R., et al. Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy. Diabetes. 2004 Nov; 53(11):2931–8. doi:10.2337/diabetes.53.11.2931.
Scott B. C., et al. Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation. Free Radic Res. 1994 Feb; 20(2):119–33. doi:10.3109/10715769409147509.
Tappel A., Fletcher B., Deamer D. Effect of antioxidants and nutrients on lipid peroxidation fluorescent products and aging parameters in the mouse. J Gerontol. 1973 Oct; 28(4):415–24. doi:10.1093/geronj/28.4.415. Thornalley P. J. Glycation in diabetic neuropathy: characteristics, consequences, causes, and therapeutic options. Int Rev Neurobiol. 2002; 50:37–7. doi:10.1016/S0074-7742(02)50072-6.
Williamson J. R., et al. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 1993 Jun; 42(6):801–13. doi:10.2337/diab.42.6.801. Ziegler D., et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis. Diabet Med. 2004 Feb; 21(2):114–21. doi:10.1111/j.1464–5491.2004.01109.
Zhou L., et al. α-Lipoic acid ameliorates mitochondrial impairment and reverses apoptosis in FABP3-overexpressing embryonic cancer cells. J Bioenerg Biomembr. 2013 Oct;45(5): 459–66. Epub 2013 Mar 28.
Andrews R., et al. The effect of dietary creatine supplementation on skeletal muscle metabolism in congestive heart failure. Eur Heart J. 1998 Apr; 19(4):617–22.
Balestrino M., et al. Role of creatine and phosphocreatine in neuronal protection from anoxic and ischemic damage. Amino Acids. 2002; 23(1–3):221–9. doi:10.1007/s00726-001-0133-3.
Broqvist M., et al. Nutritional assessment and muscle energy metabolism in severe chronic congestive heart failure — effects of long-term dietary supplementation. Eur Heart J. 1994 Dec;15(12):1641–50. doi:10.1093/ oxfordjournals.eurheartj.a060447.
Ferrante R. J., et al. Neuroprotective effects of creatine in a transgenic mouse model of Huntington’s disease. J Neurosci. 2000 Jun 15;20(12):4389–97. Field M. L. Creatine supplementation in congestive heart failure [letter]. Cardiovasc Res 1996 Jan; 31(1):174–6.
Gordon A., et al. Creatine supplementation in chronic heart failure increases skeletal muscle creatine phosphate and muscle performance. Cardiovasc Res. 1995 Sep; 30(3):413–8.
Klivenyi P., et al. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat Med. 1999 Mar; 5(3):347–50. doi:10.1038/6568.
Malcon C., Kaddurah-Daouk R., Beal M. F. Neuroprotective effects of creatine administration against NMDA and malonate toxicity. Brain Res. 2000 Mar 31; 860(1–2):195–8. doi:10.1016 /S0006-8993(00)02038-2.
Matthews R. T., et al. Neuroprotective effects of creatine and cyclocre-atine in animal models of Huntington’s disease. J Neurosci. 1998 Jan; 18(1):156–63.
Matthews R. T., et al. Creatine and cyclocreatine attenuate MPTP neurotoxicity. Exp Neurol. 1999 May; 157(1):142–9. doi:10.1006/exnr.1999.7049. Park J. H., et al. Use of P-31 magnetic resonance spectroscopy to detect metabolic abnormalities in muscles of patients with fibromyalgia. Arthritis Rheum. 1998 Mar; 41(3):406–13. doi:10.1002/1529-0131(199803)41:3<406::AID-ART5>3.0.CO;2-L.
Tarnopolsky M., Martin J. Creatine monohydrate increases strength in patients with neuromuscular disease. Neurology. 1999 Mar 10; 52(4):854–7.
Walter M. C., et al. Creatine monohydrate in muscular dystrophies: a double blind, placebo-controlled clinical study. Neurology. 2000 May 9; 54(9):1848–50.
Bernsen P. L., et al. Successful treatment of pure myopathy, associated with complex I deficiency, with riboflavin and carnitine. Arch Neurol. 1991 Mar; 48(3):334–8. doi:10.1001/archneur.1991.00530150106028.
Bernsen P. L., et al. Treatment of complex I deficiency with riboflavin. J Neurol Sci. 1993 Sep; 118(2):181–7. doi:10.1016/0022-510X(93)90108-B. Bettendorff L., et al. Low thiamine diphosphate levels in brains of patients with frontal lobe degeneration of the non-Alzheimer’s type. J Neurochem. 1997 Nov; 69(5):2005–10. doi:10.10 46/j.1471–4159.1997.69052005.
Bogan K. L., Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Annu Rev Nutr. 2008; 28: 115–30. doi:10.1146/annurev. nutr.28.061807.155443.
Bottiglieri T. Folate, vitamin B12, and s-adenosylmethionine. Psychiatr Clin North Am. 2013 Mar;36(1):1–13. doi:10.1016/j.psc.2012.12.001.
Bugiani M., et al. Effects of riboflavin in children with complex II deficiency. Brain Dev. 2006 Oct; 28(9):576–81. doi:10.1016/j.braindev.2006.04.001. Cantó C., et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838–47. doi:10.1016/j.cmet.2012.04.022.
Czerniecki J., Czygier M. Cooperation of divalent ions and thiamin diphosphate in regulation of the function of pig heart pyruvate dehydrogenase complex. J Nutr Sci Vitaminol (Tokyo). 2001 Dec; 47(6):385–6.
Denu J. M. Vitamins and aging: pathways to NAD+ synthesis. Cell. 2007 May 4;129(3):453–4. doi:10.1016/j.cell.2007.04.023.
Garbin L., Plebani M., Terribile P. M. Effect of ACP (pyridoxine-2-oxo-glutarate) on CCl4 intoxication and in streptozotocin-induced ketosis in rat. Acta Vitaminol Enzymol. 1977;31(6):175–8.
Gerards M., et al. Riboflavin-responsive oxidative phosphorylation complex I deficiency caused by defective ACAD9: new function for an old gene. Brain. 2011 Jan; 134(Pt 1):210–9. doi:10.1093/brain/awq273.
Hartman T. J., et al. Association of the B-vitamins pyridoxal 5’-phosphate (B(6)), B(12), and folate with lung cancer risk in older men. Am J Epidemiol. 2001 Apr 1; 153(7):688–94. doi:10.1093/aje/153.7.688.
Iliev I. S., et al. Enzyme activity changes in chronic alcoholic intoxication and the simultaneous administration of pyridoxine. Vopr Pitan. 1982 Nov; (6):54–6.
Imai S. I., Guarente L. NAD(+) and sirtuins in aging and disease. Trends Cell Biol. 2014 Aug; 24(8):464–71. Epub 2014 Apr 28. doi:10.1016/j. tcb.2014.04.002.
Ke Z. J., et al. Reversal of thiamine deficiency-induced neurodegeneration. J Neuropathol Exp Neurol. 2003 Feb;62(2):195–207. doi:10.1093/ jnen/62.2.195.
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