Дэниел Левитин - Счастливое старение. Рекомендации нейробиолога о том, как жить долго и хорошо

J. G. Ruby et al., “Estimates of the Heritability of Human Longevity Are Substantially Inflated Due to Assortative Mating,” Genetics 210, no. 3 (2018): 1109–1124.

M. Molteni, “The Key to Long Life Has Little to Do with ‘Good Genes,’ ” Wired, November 6, 2018.

S. Ryu et al., “Genetic Landscape of APOE in Human Longevity Revealed by High-Throughput Sequencing,” Mechanisms of Ageing and Development 155 (2016): 7–9.

R. Martins, G. J. Lithgow, and W. Link, “Long Live FOXO: Unraveling the Role of FOXO Proteins in Aging and Longevity,” Aging Cell 15, no. 2 (2016): 196–207.

Кеньон сделала это не прямо, а посредством манипуляций с передачей инсулиноподобных сигналов перед геном FOXO.

C. Kenyon, “Experiments That Hint of Longer Lives,” TEDGlobal, November 17, 2011, https://www.ted.com/talks/cynthia_kenyon_experiments_that_hint_of_longer_lives/transcript#t-157928.

Из личного общения с Синтией Кеньон 28 февраля 2016 года.

H. Hsin and C. Kenyon, “Signals from the Reproductive System Regulate the Lifespan of C. elegans,” Nature 399, no. 6734 (1999): 362.

J. B. Hamilton and G. E. Mestler, “Mortality and Survival: Comparison of Eunuchs with Intact Men and Women in a Mentally Retarded Population,” Journal of Gerontology 24, no. 4 (1969): 395–411.

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K. A. Bohnert and C. Kenyon, “A Lysosomal Switch Triggers Proteostasis Renewal in the Immortal C. elegans Germ Lineage,” Nature 551, no. 7682 (2017): 629; C. Zimmer, “Young Again: How Mating Turns Back Time,” The New York Times, November 22, 2017, p. D3.

C. Kenyon, “The Genetics of Ageing,” Nature (2010): 464, 504–512.

L. Hayflick, “Human Cells and Aging,” Scientific American 218, no. 3 (1968): 32–37.

J. Cepelewicz, “Ingenious: Leonard Hayflick,” Nautilus, November 24, 2016, http://nautil.us/issue/42/fakes/ingenious-leonard-hayflick.

Российский биолог Алексей Оловников придумал аналогию с поездом метро и тоннелем, но мне так и не удалось понять его логику и представить себе, о чем он говорит. A. M. Olovnikov, “Telomeres, Telomerase, and Aging: Origin of the Theory,” Experimental Gerontology 31, no. 4 (1996): 443–448.

M. Armanios and E. H. Blackburn, “The Telomere Syndromes,” Nature Reviews Genetics 13, no. 10 (2012): 693.

G. W. Edmonds, H. C. Côté, and S. E. Hampson, “Childhood Conscientiousness and Leukocyte Telomere Length 40 Years Later in Adult Women – Preliminary Findings of a Prospective Association,” PLoS One 10, no. 7 (2015): e0134077.

N. C. Arsenis et al., “Physical Activity and Telomere Length: Impact of Aging and Potential Mechanisms of Action,” Oncotarget 8, no. 27 (2017): 45008; E. Puterman et al., “The Power of Exercise: Buffering the Effect of Chronic Stress on Telomere Length,” PLoS One 5, no. 5 (2010): e10837; J. H. Kim et al., “Habitual Physical Exercise Has Beneficial Effects on Telomere Length in Postmenopausal Women,” Menopause 19, no. 10 (2012): 1109–1115.

J. Y. Lee et al., “Association between Dietary Patterns in the Remote Past and Telomere Length,” European Journal of Clinical Nutrition 69, no. 9 (2015): 1048; N. Rafie et al., “Dietary Patterns, Food Groups and Telomere Length: A Systematic Review of Current Studies,” European Journal of Clinical Nutrition 71, no. 2 (2017): 151; A. M. Fretts et al., “Processed Meat, but Not Unprocessed Red Meat, Is Inversely Associated with Leukocyte Telomere Length in the Strong Heart Family Study,” Journal of Nutrition 146, no. 10 (2016): 2013–2018.

S. Y. Gebreab et al., “Perceived Neighborhood Problems Are Associated with Shorter Telomere Length in African American Women,” Psychoneuroendocrinology 69 (2016): 90–97; B. L. Needham et al., “Neighborhood Characteristics and Leukocyte Telomere Length: The MultiEthnic Study of Atherosclerosis,” Health and Place 28 (2014): 167–172.

T. G. Son, S. Camandola, and M. P. Mattson, “Hormetic Dietary Phytochemicals,” Neuromolecular Medicine 10, no. 4 (2008): 236.

E. Blackburn and E. Epel, The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer (New York: Hachette, 2017). ( Эпель Э., Блэкберн Э. Эффект теломер. Революционный подход к более молодой, здоровой и долгой жизни. М.: Эксмо, 2017.)

Blackburn and Epel, The Telomere Effect.

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J. Mogil, “What’s Wrong with Animal Models of Pain?” The Opioid Crisis and the Future of Addiction and Pain Therapeutics: Opportunities, Tools, and Technologies Symposium, Washington, DC, February 2019, video, at 30:35: https://videocast.nih.gov/summary.asp?Live=31408&bhcp=1.

University of Pittsburgh Schools of the Health Sciences, “Telomere Length Predicts Cancer Risk,” ScienceDaily, April 3, 2017, www.sciencedaily.com/releases/2017/04/170403083123.htm; J. M. Yuan et al., “A Prospective Assessment for Telomere Length in Relation to Risk of Cancer in the Singapore Chinese Health Study,” AACR Annual Meeting, Washington, DC, April 2017.

F. P. Barthel et al., “Systematic Analysis of Telomere Length and Somatic Alterations in 31 Cancer Types,” Nature Genetics 49, no. 3 (2017): 349. См. также: P. C. Haycock et al., “Association between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study,” JAMA Oncology 3, no. 5 (2017): 636–651.

Издана на русском языке: Эпель Э., Блэкберн Э. Эффект теломер. Революционный подход к более молодой, здоровой и долгой жизни. М.: Эксмо, 2017.

Blackburn and Epel, The Telomere Effect.

Из личного общения с Зигфридом Хекими 26 марта 2019 года.

D. Warmflash, “Liz Parrish Is Patient Zero in Her Own Anti-Aging Experiment,” The Crux, April 29, 2016, http://blogs.discovermagazine.com/crux/2016/04/29/liz-parrish-is-an-ceo-and-patient-zero/#.XLdySpNKjox.

J. W. Shay, “Role of Telomeres and Telomerase in Aging and Cancer,” Cancer Discovery 6, no. 6 (2016): 584–593.

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S. J. Olshansky, “Is Life Extension Today a Faustian Bargain?” Frontiers in Medicine 4 (2017): 215.

K. McLaughlin and R. Winslow, “Report Details Dr. Atkins’s Health Problems,” The Wall Street Journal, February 10, 2004, https://www.wsj.com/articles/SB107637899384525268.

P. Kennedy, “No Magic Pill Will Get You to 100,” The New York Times, March 9, 2018, p. SR1.

D. Cavett, “When That Guy Died on My Show,” The New York Times, May 3, 2007, https://opinionator.blogs.nytimes.com/2007/05/03/when-that-guy-died-on-my-show/.

D. J. Baker et al., “Clearance of p16 Ink4a-Positive Senescent Cells Delays Ageing-Associated Disorders,” Nature 479, no. 7372 (2011): 232.

M. Scudellari, “To Stay Young, Kill Zombie Cells,” Nature 550, no. 7677 (2017): 448–450.

M. J. Schafer et al., “Cellular Senescence Mediates Fibrotic Pulmonary Disease,” Nature Communications 8 (2017): 14532; O. H. Jeon et al., “Local Clearance of Senescent Cells Attenuates the Development of PostTraumatic Osteoarthritis and Creates a Pro-Regenerative Environment,” Nature Medicine 23, no. 6 (2017): 775; D. J. Baker et al., “Naturally Occurring p16 Ink4aPositive Cells Shorten Healthy Lifespan,” Nature 530, no. 7589 (2016): 184.

T. J. Bussian et al., “Clearance of Senescent Glial Cells Prevents Tau-Dependent Pathology and Cognitive Decline,” Nature 562, no. 7728 (2018): 578.

Scudellari, “To Stay Young, Kill Zombie Cells.”

Scudellari, “To Stay Young, Kill Zombie Cells.”

Z. Corbyn, “Want to Live for Ever? Flush Out Your Zombie Cells,” The Guardian, October 6, 2018, https://www.theguardian.com/science/2018/oct/06/race-to-kill-killer-zombie-cells-senescent-damaged-ageing-eliminate-research-mice-aubrey-de-grey.

Цит. по: Corbyn, “Want to Live for Ever?”

Из личного общения с Джеем Эллисоном 28 июля 2018 года.

Из личного общения с Джеем Эллисоном 28 июля 2018 года.

F. S. Hodi et al., “Two-Year Overall Survival Rates from a Randomised Phase 2 Trial Evaluating the Combination of Nivolumab and Ipilimumab versus Ipilimumab Alone in Patients with Advanced Melanoma,” Lancet Oncology 17, no. 11 (2016): 1558.

A. Aoyagi et al., “Aβ and Tau Prion-Like Activities Decline with Longevity in the Alzheimer’s Disease Human Brain,” Science Translational Medicine 11, no. 490 (2019): eaat8462.

Из личного общения со Стенли Прузинером 12 сентября 2019 года.