Владимир Скулачёв - Жизнь без старости
- Название:Жизнь без старости
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- Издательство:МГУ им. М.В.Ломоносова
- Год:2014
- ISBN:нет данных
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Владимир Скулачёв - Жизнь без старости краткое содержание
Не исключено, что это только начало пути, и уже в ближайшие годы будет создан препарат, предохраняющий от старости. Чтобы дожить до этого будущего, авторы предлагают 7 принципов, выведенных на основе биологического проникновения в глубинную природу человека. Каждый из принципов понятен и достаточно легко выполним, если вами движет любовь к жизни и своим близким. Следуя этим принципам, можно замедлить генетическую программу старения и заставить свой организм думать, что ему рано стареть.
Прочитайте, приблизьтесь к фонтану молодости — и живите долго!
Жизнь без старости - читать онлайн бесплатно полную версию (весь текст целиком)
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[224] Migliaccio E., Giorgio M., Mele S., Pelicci G., Reboldi P., Pandolfi P.P., Lanfrancone L., Pelicci P.G. (1999) The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402, 6759, 309-13.
[225] Miki H., Funato Y. (2012) Regulation of intracellular signalling through cysteine oxidation by reactive oxygen species. J Biochem 151, 3, 25561.
[226] Milewski L.A.K. (2010) The evolution of ageing. Bioscience Horizons 3, 1, 77–84.
[227] Miller R.A., Buehner G., Chang Y., Harper J.M., Sigler R., Smith-Wheelock M. (2005) Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4, 3, 119-25.
[228] Mitteldorf J. Sagan D. (in press, 2014) Suicide genes, MacMillan Press
[229] Mott J.L., Zhang D., Freeman J.C., Mikolajczak P., Chang S.W., Zassenhaus H.P. (2004) Cardiac disease due to random mitochondrial DNA mutations is prevented by cyclosporin A. Biochem Biophys Res Commun 319, 4, 1210-5.
[230] Muller H.J. (1938) The re-making of chromosomes. Collecting Net (Woods Hole) 13, 181–198.
[231] Murphy M.P., Holmgren A., Larsson N.G., Halliwell B., Chang C.J., Kalyanaraman B., Rhee S.G., Thornalley P.J., Partridge L., Gems D., Nystrom T., Belousov V., Schumacker P.T., Winterbourn C.C. (2011) Unraveling the biological roles of reactive oxygen species. Cell Metab 13, 4, 361-6.
[232] Murphy M.P., Smith R.A. (2007) Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol 47, 629-56.
[233] Murray T.V., McMahon J.M., Howley B.A., Stanley A., Ritter T., Mohr A., Zwacka R., Fearnhead H.O. (2008) A non-apoptotic role for caspase-9 in muscle differentiation. J Cell Sci 121, Pt 22, 3786-93.
[234] Nader G.A., Lundberg I.E. (2009) Exercise as an anti-inflammatory intervention to combat inflammatory diseases of muscle. Curr.Opin.Rheumatol 21, 6, 599–603.
[235] Nagai R., Ikeda K., Higashi T., Sano H., Jinnouchi Y., Araki T., Horiuchi S. (1997) Hydroxyl radical mediates N epsilon-(carboxymethyl)lysine formation from Amadori product. Biochem Biophys Res Commun 234, 1, 167-72.
[236] Napoli C., Martin-Padura I., de Nigris F., Giorgio M., Mansueto G., Somma P., Condorelli M., Sica G., De Rosa G., Pelicci P. (2003) Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. Proc Natl Acad Sci U S A 100, 4, 2112-6.
[237] Narendra D.P., Youle R.J. (2011) Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control. Antioxid Redox Signal 14, 10, 1929-38.
[238] Neumann P.M., Tucker A.T., Nooden L.D. (1983) Characterization of leaf senescence and pod development in soybean explants. Plant Physiol 72, 1, 182-5.
[239] Nooden L.D., Murray B.J. (1982) Transmission of the monocarpic senescence signal via the xylem in soybean. Plant Physiol 69, 4, 754756.
[240] Nystrom T. (2005) Role of oxidative carbonylation in protein quality control and senescence. EMBO J 24, 7, 1311-7.
[241] Obin M., Halbleib M., Lipman R., Carroll K., Taylor A., Bronson R. (2000) Calorie restriction increases light-dependent photoreceptor cell loss in the neural retina of Fischer 344 rats. Neurobiol Aging 21, 5, 639-45.
[242] Obukhova L.A., Skulachev V.P., Kolosova N.G. (2009) Mitochondria-targeted antioxidant SkQ1 inhibits age-dependent involution of the thymus in normal and senescence-prone rats. Aging (Albany) 1, 4, 389–401.
[243] Olivieri F., Rippo M.R., Monsurro V., Salvioli S., Capri M., Procopio A.D., Franceschi C. (2013) MicroRNAs linking inflamm-aging, cellular senescence and cancer. Ageing Res Rev 12, 4, 1056-68.
[244] Olovnikov A.M. (1971) Id! da! d v! $!!" [Principle of marginotomy in template synthesis of polynucleotides]. Dokl.Akad.Nauk SSSR. 201, 6, 1496–1499.
[245] Orrenius S., Gogvadze V., Zhivotovsky B. (2007) Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol 47, 143-83.
[246] Osiewacz H.D. (2003) Aging and mitochondrial dysfunction in the filamentous fungus Podospora anserina. Topics in Current Genetics (Nystrom, T., Osiewacz, H. D.), 17–38. Springer-Verlag Berlin Heidelberg.
[247] Osthus I.B., Sgura A., Berardinelli F., Alsnes I.V., Bronstad E., Rehn T., Stobakk P.K., Hatle H., Wisloff U., Nauman J. (2012) Telomere length and long-term endurance exercise: does exercise training affect biological age? A pilot study. PLoS.One. 7, 12, e52769.
[248] Ott M., Gogvadze V., Orrenius S., Zhivotovsky B. (2007) Mitochondria, oxidative stress and cell death. Apoptosis 12, 5, 913-22.
[249] Ozdemir M., Temizdemir H. (2010) Age- and gender-related tear function changes in normal population. Eye 24, 1, 79–83.
[250] Paglialunga S., van Bree B., Bosma M., Valdecantos M.P., Amengual-Cladera E., Jorgensen J.A., van Beurden D., den Hartog G.J., Ouwens D.M., Briede J.J., Schrauwen P., Hoeks J. (2012) Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice. Diabetologia 10.1007/s00125-012-2626-x, (accepted).
[251] Palm W., de Lange T. (2008) How shelterin protects mammalian telomeres. Annu.Rev.Genet. 42:301-34. doi: 10.1146/annurev.genet.41.110306.130350., 301–334.
[252] Palmer A.K., Street A.E., Roe F.J.C., Worden A.N., Vanabbe N.J. (1979) Safety evaluation of toothpaste containing chloroform. 2. Long-term studies in rats. JEnvir Pathol Toxicol 2, 3, 821–833.
[253] Pamplona R., Portero-Otin M., Riba D., Ruiz C., Prat J., Bellmunt M.J., Barja G. (1998) Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals. J Lipid Res 39, 10, 1989-94.
[254] Paradies G., Petrosillo G., Paradies V., Ruggiero F.M. (2010) Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging. Free Radic Biol Med 48, 10, 1286-95.
[255] Park S.K., Kim K., Page G.P., Allison D.B., Weindruch R., Prolla T.A.(2009) Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants. Aging Cell 8, 4, 484-95.
[256] Parrinello S., Samper E., Krtolica A., Goldstein J., Melov S., Campisi J. (2003) Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat.Cell Biol. 5, 8, 741–747.
[257] Patten D.A., Lafleur V.N., Robitaille G.A., Chan D.A., Giaccia A.J., Richard D.E. (2010) Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species. Mol Biol Cell 21, 18, 3247-57.
[258] Penninx B.W., van Tilburg T., Kriegsman D.M., Deeg D.J., Boeke A.J., van Eijk J.T. (1997) Effects of social support and personal coping resources on mortality in older age: the longitudinal aging study. Am J Epidemiol 146, 6, 510-9.
[259] Pepper J.W., Shelton D.E., Rashidi A., Durand P.M. (2013) Are internal, death-promoting mechanisms ever adaptive? J Phylogen Evolution Biol 1, 3, 1000113.
[260] Petrosillo G., Matera M., Casanova G., Ruggiero F.M., Paradies G. (2008) Mitochondrial dysfunction in rat brain with aging. Involvement of complex I, reactive oxygen species and cardiolipin. Neurochem Int 53, 5, 126-31.
[261] Piddock L.J., Walters R.N. (1992) Bactericidal activities of five quinolones for Escherichia coli strains with mutations in genes encoding the SOS response or cell division. Antimicrob.Agents Chemother. 36, 4, 819–825.
[262] Pierpaoli W., Bulian D. (2005) The pineal aging and death program: life prolongation in pre-aging pinealectomized mice. Ann N Y Acad Sci 1057, 133-44.
[263] Plotnikov E.Y., Chupyrkina A.A., Jankauskas S.S., Pevzner I.B., Silachev D.N., Skulachev V.P., Zorov D.B. (2011) Mechanisms of nephroprotective effect of mitochondria-targeted antioxidants under rhabdomyolysis and ischemia/reperfusion. Biochim Biophys Acta 1812, 1, 77–86.
[264] Plotnikov E.Y., Kazachenko A.V., Vyssokikh M.Y., Vasileva A.K., Tcvirkun D.V., Isaev N.K., Kirpatovsky V.I., Zorov D.B. (2007) The role of mitochondria in oxidative and nitrosative stress during ischemia/reperfusion in the rat kidney. Kidney Int 72, 12, 1493-502.
[265] Plotnikov E.Y., Morosanova M.A., Pevzner I.B., Zorova L.D., Manskikh V.N., Pulkova N.V., Galkina S.I., Skulachev V.P., Zorov D.B. (2013) Protective effect of mitochondria-targeted antioxidants in an acute bacterial infection. PNAS doi/10.1073/pnas.1307096110
[266] Pozniakovsky A.I., Knorre D.A., Markova O.V., Hyman A.A., Skulachev V.P., Severin F.F. (2005) Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast. J Cell Biol 168, 2, 257–269.
[267] Prowse K.R., Greider C.W. (1995) Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc.Natl.Acad.Sci.U.S.A. 92, 11, 4818–4822.
[268] Puigserver P., Wu Z., Park C.W., Graves R., Wright M., Spiegelman B.M. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 92, 6, 829–839.
[269] Qiu X., Brown K., Hirschey M.D., Verdin E., Chen D. (2010) Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 12, 6, 662-7.
[270] Radak Z., Hart N., Sarga L., Koltai E., Atalay M., Ohno H., Boldogh I.(2010) Exercise plays a preventive role against Alzheimer's disease. J.Alzheimers.Dis. 20, 3, 777–783.
[271] Radak Z., Naito H., Kaneko T., Tahara S., Nakamoto H., Takahashi R., Cardozo-Pelaez F., Goto S. (2002) Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle. Pflugers Arch. 445, 2, 273–278.
[272] Radogna F., Cristofanon S., Paternoster L., D'Alessio M., De Nicola M., Cerella C., Dicato M., Diederich M., Ghibelli L. (2008) Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2. J Pineal Res 44, 3, 316-25.
[273] Rae M.J., Butler R.N., Campisi J., de Grey A.D., Finch C.E., Gough M., Martin G.M., Vijg J., Perrott K.M., Logan B.J. (2010) The demographic and biomedical case for late-life interventions in aging. Sci Transl Med 2, 40, 40cm21.
[274] Ramsgaard L., Englert J.M., Manni M.L., Milutinovic P.S., Gefter J., Tobolewski J., Crum L., Coudriet G.M., Piganelli J., Zamora R., Vodovotz Y., Enghild J.J., Oury T.D. (2011) Lack of the receptor for advanced glycation end-products attenuates E. colipneumonia in mice. PLoS One 6, 5, e20132.
[275] Rattan S.I. (2005) Anti-ageing strategies: prevention or therapy? Showing ageing from within. EMBO Rep 6 Spec No, S25-9.
[276] Redman L.M., Ravussin E. (2011) Caloric restriction in humans: impact on physiological, psychological, and behavioral outcomes. Antioxid Redox Signal 14, 2, 275-87.
[277] Remolina S.C., Hughes K.A. (2008) Evolution and mechanisms of long life and high fertility in queen honey bees. Age (Dordr) 30, 2–3, 177-85.
[278] Richie J.P., Jr., Leutzinger Y., Parthasarathy S., Malloy V., Orentreich N., Zimmerman J.A. (1994) Methionine restriction increases blood glutathione and longevity in F344 rats. FASEB J 8, 15, 1302-7.
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