Чарльз Эллис - Эпигенетика

Хотя все это было представлено в виде последовательного рассказа, более правильным был бы взгляд на эти события, как на ряд параллельных и перекрывающихся попыток определить и объяснить эпигенетические явления. Определение термина «эпигенетика» изменилось, но вопросы относительно механизмов развития, поставленные более ранними поколениями ученых, остались прежними. Современная эпигенетика все еще обращается к этим центральным вопросам. Семьдесят лет прошло с тех пор, как Меллер описал явление, называемое сейчас эффектом положения мозаичного типа. Доставляет удовольствие проследить этот медленный прогресс от наблюдения фенотипов, через элегантные генетические исследования, к современному анализу и решению проблем на молекулярном уровне. Вместе с этими знаниями пришло понимание того, что в действительности эпигенетические механизмы могут отвечать за значительную часть фенотипа сложных организмов. Как нередко случается, наблюдение, показавшееся вначале хотя и интересным, но, возможно, маргинальным по отношению к главным проблемам, оказывается центральным, хотя для осознания этого может понадобиться много времени.

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