Джейн Плант - Антирак груди

– ЭФР (эпидермальный фактор роста) [439] Murphy, M.S. and others, 1998. Growth factors and the gastrointestinal tract. Nutrition , 14 (10), 771–774; Buts, J.F., 1998, Bioactive factors in milk. (in French.) Archives de Pediatrie , 5 (3), 298–306. . Подобно ИФР, ЭФР трудно разрушить ферментами [440] Shen, W.H. and others, 1998. Stability and distribution of orally administered epidermal growth factor in neonatal pigs. Life Sciences , 63 (10), 809–820; Rao, R.K. and others, 1998. Bovine milk inhibits proteolytic degradation of epidermal growth factor in human gastric and duodenal lumen. Peptides , 19 (3), 495–504; McCuskey, R.S. and others, 1997. Effect of milkborne epidermal growth factor on the hepatic microcirculation and Kupfer cell function in suckling rats. Biology of the Neonate , 7 (3), 202–206; Oguchi, S. and others, 1997. Growth factors in breast milk and their effect on gastrointestinal development. Chang Hua Min Kuo Hsiao Ehr Ko I Hsuek Tsa Chih , 38 (5), 332–337. . ЭФР усиливает развитие рака груди [441] Salomon, D.S. and others, 1999. Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia. Bioessays , 21 (1), 61–70; Chou, Y.C. and others, 1999. Induction of mammary carcinomas by N-methyl-N-nitrosurea in ovariectomized rats treated with epidermal growth factor. Carcinogenesis , 20 (4), 677–684; Kurtz, A. and others, 1998. Local control of mammary gland differentiation: mammary-derived growth inhibitor and pleiotrophin. Biochemical Society Symposium , 63, 51–69; Taylor, M.R. and others, 1997. Lactadherin (formerly BA46); a membrane-associated gycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion. DNA and Cell Biology , 16 (7), 861–869. и рака простаты [442] Zhau, H.J. and others, 1996. Androgen-depressed phenotype in human prostate cancer. Proc. Natl. Acad. Sci. U.S.A ., 93 (26), 15 152-15 157. и был первым фактором роста, для которого получили доказательство его абсорбции стенками кишечника [443] Thornburg, W. and others, 1984. Gastrointestinal absorption of epidermal growth factor in suckling rats. American Journal of Physiology , 246, G80-G85. . Его необходимо избегать тем, чьи опухоли перепроизводят белок HER-2. ЭФР связан с андрогеннезависимым раком простаты [444] www.prostatepointers.org/cmyers/pf0696.html .

– ФРН (фактор роста нервов) [445] Gaull, G.E. and others, 1985. Significance of growth modulators in human milk. Pediatrics , 75 (2), 142–145. .

– Эстрогены.Содержание эстрогенов в коровьем молоке вызывает серьезное беспокойство (см. выше).

– Пролактин.Чтобы вскармливать младенца, женский организм хорошо приспособился к временному повышению уровней пролактина. Мужской же приспособлен к нему плохо: опухоли, секретирующие пролактин у мужчин, больше, активнее и не поддаются лечению [446] Delgrange, E. and others, 1997. Sex related differences in the growth of prolacrinomas: a clinical and proliferation marker study. Journal of Clinical Endocrinology and Metabolism . 82 (7), 2102–2107. . Пролактин стимулирует рак груди [447] Vonderhaar, B.K., 1998, Prolactin: The forgotten hormone of human breast cancer. Pharmacology and Therapeutics , 79 (2), 169–178; Das, R. and others; 1996. Involvement of SHC, GRB2, SOS and RAS in prolactin signal transduction in mammary epithelial cells. Oncogene , 13 (6), 1139–1145; Mershon, J, and others, 1995. Prolactin is a local growth factor in rat mammary tumors. Endocrinology , 136 (8), 3619–3623; Ginsberg, E. and others, 1995. Prolactin secretion by human breast cancer cells. Cancer Res , 55 (12), 2591–2595; Fuh, G. and others, 1995. Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines. J. Biol Chem , 270 (22), 13 133-13 137. и рак простаты [448] Leav, I. and others, 1999. Prolactin receptor expression in the developing human prostate and in hyperplastic, dysplastic, and neoplastic lesions. American Journal of Pathology , 154 (3), 863–870; Horti, J. and others, 1998. A phase 2 study of bromocriptine in patients with androgen-independent prostate cancer. Oncology Reports , 5 (4), 893–896; Franklin, R.B. and others, 1997. Prolactin regulation of mitochondrial aspartate aminotransferase and proteinkinase C Molecular and Cellular Endocrinology , 127 (1), 19–25; Janssen, T. and others, 1996. In vitro characterization of prolactin-induced effects on proliferation in the neoplastic LNCaP, DU145, and PC3 models of the human prostate. Cancer , 77 (1), 144–149; Janssen, T. and others, 1995. Organ culture of human tissue as study model of hormonal and pharmacological regulation of benign prostatic hyperplasia and of prostatic cancer, (frans) Acta Urol Belg , 63 (1), 7-14; Oliver, R.T. and others, 1995. New directions with hormone therapy in prostate cancer: possible benefit from blocking prolactin and use of hormone treatment intermittently in combination with immunotherapy. Eur. J. Cancer , 31A (6), 859–860; Rana, A. and others, 1995. A case for synchronous reduction of testicular androgen, adrenal androgen and prolactin for the treatment of advanced carcinoma of the prostate. Eur. J. Cancer , 31A (6), 871–875. .

– Пролактин-высвобождающий пептид [449] Hinuma, S. and others, 1998. A prolactin-releasing peptide in the brain. Nature , 393 (6682), 272–276. .

– Высвобождающий фактор лютеинизирующего гормона ( ВФЛГ) (стимулирует секрецию лютеинизирующего и фолликулостимулирующего гормонов) [450] Smith, S.S. and others, 1986. Presence of luteinising hormonereleasing hormone (LHRH) in milk. Endocrinol Exp., 2 °C2-3), 147–153; Koldovsky, O., 1989. Search for the role of milk borne biologically active peptides for the suckling. J.Nutr., 119 (II), 1543–1551; Nair, R.M. and others, 1987. Studies on LHRH and physiological fluid amino acids in human colostreum and milk. Endocrinolologia Experimentalis , 21 (1), 23–30. .

– Прогестерон [451] White, M.E. and others, 1986. Milk progesterone concentrations following simultaneous administration of buserelin and cloprostenol in cattle with normal corporal lutea. Canadian Journal of Veterinary Research , 50 (2), 285–286; Dinsmore, R.P. and others, 1989. Effect of gonadotropin-releasing hormone on clinical response and fertility in cows with cystyic ovaries, as related to milk progesterone concentration and days after partarition. Journal of the American Veterinary Medical Association, 195 (3), 327–330. .

– Пептид YY [452] Berseth, C.I. and others, 1990. Postpartum changes in pattern of gastrointestinal regulatory peptides in human milk. Am. J. Clin. Nutr., 51 (6), 985–990. .

– Пептид гистидин метионин [453] Berseth, C.I. and others, 1990. Postpartum changes in pattern of gastrointestinal regulatory peptides inhuman milk. Am. J. Clin. Nutr., 51 (6), 985–990. .

– Нейропептид Y (стимулирует аппетит) [454] Flood, J.F. and others, 1991. Increased food intake by neuropeptide Y is due to an increased motivation to eat. Peptides , 12 (6), 1329–1332. .

– Тиролиберин (стимулирует высвобождение тиреотропного гормона) [455] Amarant, T. and others, 1982. Luteinising hormone-releasing hormone and thyrotropin-releasing hormone in human and bovine milk. European Journal of Biochemistry , 127 (3), 647–650; Baram, T and others, 1977. Gonadotropin-releasing hormone in milk. Science , 198 (4314), 300–302. . Тиролиберин стимулирует секрецию пролактина [456] Koike, K. and others, 1997. The pituitary folliculo-stellate cell line TtT/GF augments basal and TRH-inducedprolactin secretion by GH3 cells. Life Sci , 61 (25), 2491–2497; Tyson, J.E. and others, 1975. The influence of prolactine secretion on human lactation. J. Clin. Endocrinol Metab , 40 (5), 764–773. и гормона роста через Т3 [457] Grochowska, R. and others, 1999. Stimulated growth hormone (GH) release in Friesian cattle with respect to GH genotypes. Reproduction Nutrition Development , 39 (2), 171–180; Bourne, R.A. and others, 1977. Serum growth hormone concentrations after growth hormone or thyroid-releasing hormone in cows. Journal of Dairy Science , 60 (10), 1629–1635. , [458] Chomczinsky, P. and others, 1993. Stimulatory effect of thyroid hormone on growth hormone gene expression in a human pituitary cell line. J. Clin. Endocrinol Metab , 77 (1), 281–285; Reynolds, A.M., 1991. The effects of chronic exposure to supra physiological concentrations of 3,5,3-triiodo-L-thyronine (T3) on cultured GC cells. Journal of Cellular. Physiology , 149 (3), 544–547. .

– Тиреотропный гормон (стимулирует секрецию Т3 и Т4) [459] Tenore, A. and others, 1980. Thyroidal response to peroral TSH in suckling and weaned rats. American Journal of Physiology , 238 (5), E428-430. .

– Т3 (триидотиронин) [460] Slebodzinski, A.B. and others, 1998. Triiodothyronine (T3), insulin and characteristics of 5'-monodiodinase (5'-MD) in mare's milk from partarition to 21 days post-partum. Reproduction Nutrition Development , 38 (3), 235–244. . Т3 увеличивает количество рецепторов эстрогенов, повышая эстрогеновое влияние [461] Fujimoto, N. and others, 1997. Upregulation of the estrogen receptor by triiodothyronine in rat pituitary cell lines. Journal of Steroid Biochemistry and Molecular Biology , 61 (1–2), 79–85. .

– Высвобождающий фактор гормона роста [462] Koldovsky, O., 1989. Search for the role of milk borne biologically active peptides for the suckling. J. Nutr., 119 (11), 1543–1551; Buts, J.P., 1998. Bioactive factors in milk. (in French.) Arch Pediatr , 5 (3), 298–306. . Стимулирует секрецию гормонов роста, а значит, ИФР-1 и ИФР-1I [463] Faulkner, A., 1998. Insulin-like growth factor concentrations in milk and plasma after growth hormone treatment. Biochemical Society Transactions , 26 (4), S386; Baldini, E. and others, 1994. In vivo cytokinetic effects of recombinant human growth hormone (rhGH) in patients with advanced breast carcinoma. Journal of Biological Regulators and Homeostatic Agents , 8 (4), 113–116; Scheven, B.A. and others, 1991. Effects of recombinant human insulin-like growth factor-1 and -2 (IGF) and growth hormone (GH) on the growth of normal adult human osteoblast-like cells and human osteogenic sarcoma cells. Growth Regulation , 1 (4), 160–167; Hodate, K. and others, 1990, Plasma growth hormone, insuline-like growth factor-l, and milk production response to exogenous human growth hormone-releasing factor analogs in dairy cows. Endocrinologia Japonica , 37 (2), 261–273. .