Бен Линч - Грязные гены. «Большая стирка» для вашей ДНК. Как изменить свою наследственность

37. If MTHFR is born dirty, it can have up to one hundred SNPS or even more: “MTHFR[all],” National Center for Biotechnology Information, U.S. National Library of Medicine, Accessed April 2017, https://www.ncbi.nlm.nih.gov/clinvar/?term=MTHFR[all].

38. Supports of healthy methylation: Wilcken, W. et al. “Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide,” Journal of Medical Genetics, 2003, http://jmg.bmj.com/content/40/8/619.

39. Health Conditions Related to SNPs in Your MTHFR: “Genopedia: MTHFR,” Center for Disease Control and Prevention, Accessed April 2017, https://phgkb.cdc.gov/HuGENavigator/huGEPedia.do?firstQuery=MTHFR&geneID=4524&typeSubmit=GO&check=y&typeOption=gene&which=2&pubOrderType=pubD.

40. Cobalamin/B12 found in food: “Vitamin B 12,” Oregon State University Linus Pauling Institute Micronutrient Information Center, Accessed April 2017, http://lpi.oregonstate.edu/mic/vitamins/vitamin-B12#food-sources.

6. COMT. Внимательность и жизнерадостность, или спокойствие и отрешенность COMT

41. Catechols found in quercetin: “COMT Gene,” Genetic Home Reference, 11 April, 2017, https://ghr.nlm.nih.gov/gene/COMT#resources.

42. Dopamine quinone is associated with Parkinson’s disease and ADHD medications: Miyazak, Ikuko, Asanuma, Masato. “Approaches to Prevent Dopamine Quinone-Induced Neurotoxicity,” Neurochemical Research, 04 September 2008, http://link.springer.com/article/10.1007/s11064-008-9843-1.

43. Toxicity of Methylphenidate: Sadasivan, Shankar et al. “Methylphenidate Exposure Induces Dopamine Neuron Loss and Activation of Microglia in the Basal Ganglia of Mice,” PLOS One, 21 March 2012, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033693.

44. Toxicity of Methylphenidate: Espay, AJ. et al. “Methylphenidate for gait impairment in Parkinson disease,” American Academy of Neurology, 5 April 2011, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068005/.

45. Adderall can generate dopamine-quinone: German, Christopher L., Hanson, Glen R., Fleckenstein, Annette E., “Amphetamine and Methamphetamine Reduce Striatal Dopamine Transporter Function Without Concurrent Dopamine Transporter Relocalization,” Journal of Neurochemistry, 23 August 2012, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962019/.

46. Two common reasons for magnesium deficiency: Janett, S. et al. “Hypomagnesemia Induced by Long-Term Treatment with Proton-Pump Inhibitors,” Gastroentology Research & Practice, 4 May 2015, https://www.ncbi.nlm.nih.gov/pubmed/26064102.

47. Two common reasons for magnesium deficiency: Kynast-Gales, SA, Massey, LK. “Effect of caffeine on circadian excretion of urinary calcium and magnesium,” Journal of American College of Nutrition, October 1994, https://www.ncbi.nlm.nih.gov/pubmed/7836625.

48. Damage from dioxins: Liu, J. et al. “Variants in maternal COMT and MTHFR genes and risk of neural tube defects in offspring,” Metabolic Brain Disease, 4 July 2014, https://www.ncbi.nlm.nih.gov/pubmed/24990354.

49. Hugs raise dopamine: “The Power of Love Hugs and Cuddles Have Long-Term Effects,” NIH News In Health, February 2007, https://newsinhealth.nih.gov/2007/february/docs/01features_01.htm.

7. DAO: суперчувствительность к еде и токсинам

50. Where DAO enzymes lives in your body: “AOC1 Gene (Protein Coding),” Gene Cards, Accessed April 2017, http://www.genecards.org/cgi-bin/carddisp.pl?gene=AOC1#expression.

51. DAO symptoms: “AOC1 Gene (Protein Coding),” Gene Cards, Accessed April 2017, http://www.genecards.org/cgi-bin/carddisp.pl?gene=AOC1#expression.

52. DAO causing irritable bowel disorders: Xie, Hua, He, Shao-Heng. “Roles of histamine and its receptors in allergic and inflammatory bowel diseases,” World Journal of Gastroenterology, 21 May 2005, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305649/.

53. Copper in turnip greens: “Copper,” Oregon State University Linus Pauling Institute Micronutrient Information Center, Accessed April 2017, http://lpi.oregonstate.edu/mic/minerals/copper.

54. Diurnal variations in plasma concentrations of tryptophan, tryosine, and other neutral amino acids: effect of dietary protein intake, Am J Clin Nutr, September, 1979, https://www.ncbi.nlm.nih.gov/pubmed/573061

8. MAOA: перемены настроения и тяга к углеводам

55. MAOA is involved in processing neurotransmitters: “Genopedia: MAOA,” Center for Disease Control and Prevention, Accessed April 2017, https://phgkb.cdc.gov/HuGENavigator/huGEPedia.do?firstQuery=MAOA&geneID=4128&typeSubmit=GO&check=y&typeOption=gene&which=2&pubOrderType=pubD.

56. Hydrogen peroxide leading to a neurological problem: Balmus, IM, et al. “Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches,” Oxidative Medicine and Cellular Longevity, 1 August 2016, https://www.ncbi.nlm.nih.gov/pubmed/27563374.

57. Foods with tryptophan: “Foods highest in Tryptophan,” Self Nutrition Data, Accessed April 2017, http://nutritiondata.self.com/foods-011079000000000000000.html?maxCount=60.

9. GST/GPX: проблемы с детоксикацией

58. Dirty GST related to increased inflammation: Luo, L. et al. “Recombinant protein glutathione S-transferases P1 attenuates inflammation in mice,” Molecular Immunology, 28 October 2008, https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=18962899&dopt=b.

59. Dirty GST related to overweight/obesity: National Center for Biotechnology Information, U.S. National Library of Medicine, Accessed April 2017, https://www.ncbi.nlm.nih.gov/pubmed/27657993,27281183,27271262,27179909,27113843,26429914,26329912,26295823,26295386,26252359,26044055,25880856,25606397,25532576,25010864,24840051,24839830,24716937,24664677,24205873?report=docsum.

60. Excess hydrogen peroxide relating to grey hair: Wood, JM et al. “Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair,” FASEB Journal, 23 February 2009, https://www.ncbi.nlm.nih.gov/pubmed/19237503.

61. Types of GST gene: “GST,” Gene Cards, Accessed April 2017, http://www.genecards.org/Search/Keyword?queryString=%22GST%22.

62. Microbiome combats chemical and oxidative stresses: Ziglari, Tahereh, Allameh, Abdolamir. “The Significance of Glutathione Conjugation in Aflatoxin Metabolism,” Aflatoxins — Recent Advances and Future Prospects, 23 January 2013, https://www.intechopen.com/books/aflatoxins-recent-advances-and-future-prospects/the-significance-of-glutathione-conjugation-in-aflatoxin-metabolism.

63. Ease in achieving optimal weight: National Center for Biotechnology Information, U.S. National Library of Medicine, Accessed April 2017, https://www.ncbi.nlm.nih.gov/pubmed/27657993,27281183,27271262,27179909,27113843,26429914,26329912,26295823,26295386,26252359,26044055,25880856,25606397,25532576,25010864,24840051,24839830,24716937,24664677,24205873?report=docsum.

64. Ease in achieving optimal weight: Crinnion, Walter. “Clean, Green, and Lean: Get Rid of the Toxins That Make You Fat,” Amazon, Accessed April 2017, https://www.amazon.com/Clean-Green-Lean-Toxins-That-ebook/dp/B00DNKYI8E/ref=tmm_kin_swatch_0?_encoding=UTF8&qid=&sr=.

65. Effects of low glutathione: Kut, JL. et al. “Regulation of murine T-lymphocyte function by spleen cell-derived and exogenous serotonin,” Immunopharmacology & Immunotoxicology, 1992, https://www.ncbi.nlm.nih.gov/pubmed/1294623.

66. Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease: Kidd P., Altern. Med. Rev., August, 2003, https://www.nebi.nlm.nih.gov/pubmed/12946237

67. Damaged glutathione can further damage cells: Mulherin DM, Thurnham DI, Situnayake RD. “Glutathione reductase activity, riboflavin status, and disease activity in rheumatoid arthritis,” Annals of The Rheumatic Diseases, November 1996, https://www.ncbi.nlm.nih.gov/pubmed/8976642.

68. Damaged glutathione can further damage cells: Taniguchi, M, Hara, T. “Effects of riboflavin and selenium deficiencies on glutathione and its relating enzyme activities with respect to lipid peroxide content of rat livers,” Journal of Nutritional Science and Vitaminology, June 1983, https://www.ncbi.nlm.nih.gov/pubmed/6619991.

69. Selenium in brazil nuts: “Selenium,” National Institutes of Health, Accessed April 2017, https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/.

70. Lungs need adequate hydrogen sulfide to breathe: Wang, P. et al. “Hydrogen sulfide and asthma,” Experimental Physiology, 10 June 2011, https://www.ncbi.nlm.nih.gov/pubmed/21666034

71. Fiber binds to xenobiotics: Stein, K. et al. “Fermented wheat aleurone induces enzymes involved in detoxification of carcinogens and in antioxidative defence in human colon cells,” The British Journal of Nutrition, 28 June 2010, https://www.ncbi.nlm.nih.gov/pubmed/20579402.

72. Healthy ways to sweat: Genuis, SJ, et al. “Blood, urine, and sweat (BUS) study: monitoring and elimination of bioaccumulated toxic elements,” Archives of Environmental Contamination and Toxicology, 6 November 2010, https://www.ncbi.nlm.nih.gov/pubmed/21057782.

10. NOS3: сердце

73. Blood clot lead to stroke: Loscalzo, Joseph, et al. “Nitric Oxide Insufficiency and Arterial Thrombosis,” Transactions of the American Clinical and Climatological Association, 2000, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194373/pdf/tacca00005-0216.pdf.

74. Meaning of angiogenesis: Adair TH, Montani JP. “Overview of Angiogenesis,” Angiogenesis, 2010, https://www.ncbi.nlm.nih.gov/books/NBK53238/.

75. Effects of unhealthy angiogenesis: Lee, PC. et al. “Impaired wound healing and angiogenesis in eNOS-deficient mice,” The American Journal of Physiology, October 1999, https://www.ncbi.nlm.nih.gov/pubmed/10516200.

76. Effects of unhealthy angiogenesis: Soneja, A., Drews, M., Malinski, T. “Role of nitric oxide, nitroxidative and oxidative stress in wound healing,” Pharmacologial Reports, 2005, https://www.ncbi.nlm.nih.gov/pubmed/16415491.

77. Essential hypertension: Kivi, Rose. “Just The Essentials Of Essential Hypertension,” Health Line, 21 December 2015, http://www.healthline.com/health/essential-hypertension#overview1.

78. NOS3 affects mood: Guck, Thomas P., et al. “Assessment and Treatment of Depression Following Myocardial Infarction,” American Family Physician, 15 August 2001, http://www.aafp.org/afp/2001/0815/p641.html.

79. BH4 needed for feel-good chemicals: Coopen A., et al. “Depression and tetrahydrobiopterin: the folate connection,” Journal of Affective Disorders, March-June 1989, https://www.ncbi.nlm.nih.gov/pubmed/2522108.

80. BH4 needed for feel-good chemicals: Liang, LP., Kaufman, S. “The regulation of dopamine release from striatum slices by tetrahydrobiopterin and L-arginine-derived nitric oxide,” Brain Research, 3 August 1998, https://www.ncbi.nlm.nih.gov/pubmed/9685635.

81. Primary function of NOS3: “NOS3,” Gene Cards, Accessed April 2017, http://www.genecards.org/cgi-bin/carddisp.pl?gene=NOS3&keywords=NOS3.

82. Primary function of NOS3: Loscalzo, Joseph, et al. “Nitric Oxide Insufficiency and Arterial Thrombosis,” Transactions of the American Clinical and Climatological Association, 2000, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194373/pdf/tacca00005-0216.pdf.

83. Effects from a dirty NOS3: Burke, Thomas. “Nitric oxide and its role in health and diabetes,” Diabetes in Control, Accessed April 2017, http://www.diabetesincontrol.com/wp-content/uploads/2015/10/nitric-oxide.pdf.